Description

n-(2-Aminoethyl)-2-[4-(1,1-Dimethylethyl)-3-Hydroxy-2,6-Dimethylphenyl]Acetamide-D4 Hydrochloride is a high-purity, deuterium-labeled derivative of a key phenolic amide compound, designed for advanced analytical and research applications. This deuterated standard is essential for ensuring accuracy and reliability in quantitative mass spectrometry, providing a critical internal reference for method development and validation. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors who require precise isotopic labeling for metabolic studies, pharmacokinetics, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of its non-deuterated counterpart in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds.
• Impurity Identification and Quantification: Enables precise tracking and quantification of process-related impurities or degradation products during drug substance and drug product development.
• Biomarker Analysis: Facilitates the sensitive and accurate detection of specific analytes in clinical research and diagnostic assay development.
• Environmental Fate Studies: Applied in agrochemical research to study the environmental degradation and metabolic pathways of active ingredients.
• Stable Isotope Labeling: Provides a chemically identical but isotopically distinct tool for mechanistic studies in organic synthesis and chemical biology.

Basic Information

Product Name	n-(2-Aminoethyl)-2-[4-(1,1-Dimethylethyl)-3-Hydroxy-2,6-Dimethylphenyl]Acetamide-D4 Hydrochloride
CAS No.	1794977-28-8
Molecular Formula	C₁₆H₂₁D₄N₂O₂·HCl
Molecular Weight	Approx. 324.86 g/mol (Contact for details)
Synonyms	2-[4-(tert-Butyl)-3-hydroxy-2,6-dimethylphenyl]-N-(2-aminoethyl)acetamide-d4 hydrochloride; Deuterated Phenolic Amide Hydrochloride; tert-Butylhydroxydimethylphenylacetamide-d4 ethylenediamine derivative hydrochloride; 2-[4-(1,1-Dimethylethyl)-3-hydroxy-2,6-dimethylphenyl]-N-(2-aminoethyl)acetamide-d4 hydrochloride; D4-Labeled BHT Amide Hydrochloride; Internal Standard for Antioxidant Metabolite Analysis-d4; (2,6-Dimethyl-4-tert-butyl-3-hydroxyphenyl)acetamide-d4 ethylenediamine hydrochloride
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C) and High-Resolution Mass Spectrometry (HRMS) to confirm deuteration level and identity. Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity (e.g., D4 content ≥98%), chemical purity (by HPLC), and other critical parameters. Our quality system is designed to meet the rigorous demands of GLP and research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and opened under controlled, low-humidity conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.