Description

[4-[2-(6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinolin-2-Yl)Ethyl]Phenyl]Amine-D4 is a deuterated isotopologue of a key tetrahydroisoquinoline derivative, designed for advanced research and development applications. This compound is critical for enhancing the sensitivity and reliability of analytical methods, particularly in pharmacokinetic and metabolic stability studies. It serves as an essential internal standard for scientists in pharmaceutical R&D, analytical chemistry, and forensic toxicology who require high-purity, stable-labeled reference materials.

Application

• Primary use as a stable isotope-labeled internal standard for quantitative mass spectrometry (LC-MS/MS, GC-MS).
• Metabolite identification and drug metabolism and pharmacokinetics (DMPK) studies in pharmaceutical research.
• Analytical method development and validation for the quantification of the non-deuterated parent compound in biological matrices.
• Use in forensic analysis for the precise detection and measurement of related compounds.
• Supporting research into the biological activity and mechanism of action of tetrahydroisoquinoline-based molecules.
• Application in the synthesis of other deuterated compounds for specialized research purposes.

Basic Information

Product Name	[4-[2-(6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinolin-2-Yl)Ethyl]Phenyl]Amine-D4
CAS No.	1794883-59-2
Molecular Formula	C19H19D4N2O2
Molecular Weight	315.44 g/mol
Synonyms	4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]aniline-d4; Deutetrabenazine Impurity D4; 2-[4-Aminophenethyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-d4; 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[4-aminophenethyl]isoquinoline-d4; 6,7-Dimethoxy-2-[4-aminophenethyl]-1,2,3,4-tetrahydroisoquinoline-d4; Deuterated Tetrabenazine Amine Metabolite; D4-Labeled THIQ Amine Derivative; (4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)amine-d4
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and tested under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (D-content), chemical purity, and identity confirmation. Our quality systems are designed to meet the rigorous demands of analytical reference standard applications, supporting compliance with GLP and research guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent oxidation and moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.