Description

o-Desmethyl Carvedilol-D5 is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in bioanalytical research. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methods, providing enhanced sensitivity and reliability for pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on cardiovascular drug development and therapeutic drug monitoring.

Application

• Primary use as a stable isotope-labeled internal standard for the precise quantification of carvedilol and its metabolites in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for the cardiovascular drug carvedilol, ensuring data accuracy and regulatory compliance.
• Enabling advanced metabolite profiling and drug metabolism studies to understand the biotransformation pathways of carvedilol.
• Supporting therapeutic drug monitoring (TDM) method development to optimize patient dosing regimens.
• Utilized in forensic and clinical toxicology laboratories for the specific and sensitive detection of carvedilol.
• Essential for method validation according to FDA, EMA, and ICH guidelines in bioanalytical laboratories.

Basic Information

Item	Details
Product Name	o-Desmethyl Carvedilol-D5
CAS No.	1794817-24-5
Molecular Formula	C23H21D5N2O5
Molecular Weight	Contact for details
Synonyms	1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxy-D3phenoxy)ethyl]amino]-2-propanol-D2; 4-Hydroxycarbazol-9-yl 2-[2-(2-Methoxy-D3phenoxy)ethylamino]ethyl-D2 Ether; Carvedilol D5 Metabolite; Carvedilol-d5 Impurity; 1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d5; BM 14190-d5 metabolite; Deuterated o-Desmethyl Carvedilol
EINECS	Contact for details

Quality Control

Our o-Desmethyl Carvedilol-D5 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and related substances. We support cGMP compliance for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.