Description

Vilazodone-D8 is a deuterated isotopologue of the antidepressant drug vilazodone, specifically labeled with eight deuterium atoms. This high-purity reference standard is essential for quantitative analytical applications, providing enhanced stability and reliability in mass spectrometry-based studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers for method development, pharmacokinetic research, and metabolite identification.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of vilazodone in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the parent drug and understand its metabolic pathways.
• Pharmaceutical Quality Control: Employed as a certified reference material for assay validation and impurity profiling of vilazodone active pharmaceutical ingredient (API) and finished dosage forms.
• Clinical Research: Supports clinical trial studies requiring precise and reliable measurement of vilazodone concentrations in patient samples.
• Forensic and Toxicology Testing: Aids in the development of confirmatory methods for detecting vilazodone in forensic and toxicological analyses.

Basic Information

Product Name	Vilazodone-D8
CAS No.	1794789-93-7
Molecular Formula	C26H19D8N5O2
Molecular Weight	Approx. 441.56 g/mol
Synonyms	5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide-D8; Vilazodone (phenyl-D8); Vilazodone-d8; SB-659746A-D8; EMD-68843-D8; 5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl}-2-benzofurancarboxamide-D8
EINECS	Contact for details

Quality Control

Every batch of Vilazodone-D8 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocol includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for chemical purity, isotopic purity (D-enrichment), and residual solvents, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed in a desiccated atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.