Description

Remibrutinib is a potent, highly selective, and orally bioavailable Bruton's tyrosine kinase (BTK) inhibitor. This small molecule compound is of significant interest for its targeted mechanism of action in modulating B-cell receptor signaling pathways. It is primarily utilized by pharmaceutical R&D organizations and contract manufacturing organizations (CMOs) engaged in the development of novel therapeutics for autoimmune and inflammatory disorders.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for autoimmune conditions.
• Autoimmune Disease Therapeutics: Investigated for the treatment of conditions such as chronic spontaneous urticaria, rheumatoid arthritis, and systemic lupus erythematosus (SLE).
• Oncology Research: Explored in studies targeting B-cell malignancies where BTK pathways are implicated, though primarily focused on autoimmune applications.
• Biochemical Assay Development: Used as a precise tool compound in high-throughput screening (HTS) and enzymatic assays to study BTK inhibition.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for GMP-grade manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental immunological and pharmacological research.

Basic Information

Product Name	Remibrutinib
CAS No.	1787294-07-8
Molecular Formula	C₂₃H₂₅FN₆O₂
Molecular Weight	436.48 g/mol
Synonyms	LOU064; LOU-064; (S)-5-(2-(1-Acryloylpiperidin-3-ylamino)-5-fluoropyrimidin-4-ylamino)-2-methoxy-N-methylbenzamide; 2-Methoxy-N-methyl-5-[[5-fluoro-2-[[(3S)-1-prop-2-enoyl-3-piperidyl]amino]pyrimidin-4-yl]amino]benzamide; Remibrutinib (USAN); Remibrutinibum (Latin)
EINECS	Contact for details

Quality Control

Our Remibrutinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identification by NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.