Description

Norcyclobenzaprine-D3 is a deuterated analog of the skeletal muscle relaxant cyclobenzaprine, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard in quantitative bioanalytical methods, ensuring high accuracy and reliability in pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and regulatory compliance.

Application

• Primary use as an Internal Standard in LC-MS/MS and GC-MS methods for the quantification of cyclobenzaprine and its metabolites in biological matrices.
• Critical component in Deuterium-Labeled Reference Material for method development, validation, and quality control in bioanalytical assays.
• Supporting Pharmacokinetic (PK) and Drug Metabolism Studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of cyclobenzaprine.
• Use in Doping Control and Forensic Toxicology for the precise and unambiguous identification and quantification of cyclobenzaprine.
• Application in Stable Isotope Dilution Mass Spectrometry (SID-MS) techniques to achieve the highest level of analytical accuracy.
• Essential for Regulatory Submissions to agencies like the FDA and EMA, where validated methods using appropriate internal standards are mandatory.

Basic Information

Product Name	Norcyclobenzaprine-D3
CAS No.	1784779-86-7
Molecular Formula	C20H18D3N
Molecular Weight	278.42 g/mol
Synonyms	5-(3-D3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene; Deuterated Norcyclobenzaprine; Cyclobenzaprine-d3 Impurity; Norcyclobenzaprine (trimethyl-d3); 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-(trideuteriomethyl)propan-1-amine; Nor-cyclobenzaprine-D3; Stable Isotope Labeled Norcyclobenzaprine
EINECS	Contact for details

Quality Control

Every batch of Norcyclobenzaprine-D3 is manufactured and analyzed under strict quality systems to ensure the highest chemical and isotopic purity required for critical analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide comprehensive data including assay, isotopic enrichment, and impurity profile by advanced chromatographic and spectrometric techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.