Description

(6-(Trifluoromethyl)Piperidin-2-Yl)Methanol is a specialized chiral piperidine derivative featuring a trifluoromethyl group and a hydroxymethyl substituent. This compound is a high-value building block prized for its ability to impart metabolic stability and modulate physicochemical properties in advanced molecular architectures. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including potential kinase inhibitors and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Advanced Material Research: Potential precursor for specialty chemicals and functional materials requiring fluorine-containing motifs.

Basic Information

Product Name	(6-(Trifluoromethyl)Piperidin-2-Yl)Methanol
CAS No.	1784370-07-5
Molecular Formula	C7H12F3NO
Molecular Weight	183.17 g/mol
Synonyms	2-(Hydroxymethyl)-6-(trifluoromethyl)piperidine; (6-(Trifluoromethyl)-2-piperidinyl)methanol; 6-(Trifluoromethyl)piperidine-2-methanol; 2-Piperidinemethanol, 6-(trifluoromethyl)-; α-(Trifluoromethyl)-2-piperidinemethanol
EINECS	Contact for details

Quality Control

Our production of (6-(Trifluoromethyl)Piperidin-2-Yl)Methanol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for research and scale-up activities. A detailed Certificate of Analysis (COA) providing purity, enantiomeric excess, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This fluoride-containing compound should be kept separate from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.