Description

Pyridostatin Hydrochloride CAS NO 1781882-65-2 is a high-purity, small molecule compound recognized as a potent and selective G-quadruplex stabilizer. This specificity makes it a critical research tool for investigating telomere maintenance mechanisms and genomic instability in oncology and aging research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer therapeutics and molecular biology.

Application

• Cancer Research & Drug Discovery: Used as a reference standard and active agent in studies targeting telomerase inhibition and alternative lengthening of telomeres (ALT) pathways.
• Biochemical Assay Development: Serves as a key component in high-throughput screening (HTS) assays to identify novel G-quadruplex interactive compounds.
• Academic & Molecular Biology Studies: Employed to elucidate the role of G-quadruplex structures in gene expression, replication, and genomic stability.
• Preclinical Pharmacology: Utilized in *in vitro* and *in vivo* models to evaluate antitumor efficacy and mechanism of action.
• Diagnostic Probe Development: Acts as a foundational molecule for developing fluorescent probes or other detection methods for G-quadruplex structures.

Basic Information

Product Name	Pyridostatin Hydrochloride
CAS No.	1781882-65-2
Molecular Formula	C₂₀H₂₀N₆O₂ • HCl
Molecular Weight	404.87 g/mol (Free base: 368.41 g/mol)
Synonyms	Pyridostatin HCl; 6-(4-(Dimethylamino)phenyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyridazin-3-amine hydrochloride; G-Quadruplex Stabilizer Pyridostatin; PDS hydrochloride; Telomere Targeting Agent; ALT Pathway Inhibitor
EINECS	Contact for details

Quality Control

Our Pyridostatin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.