Description

Ro 32-0432 Hydrochloride is a potent and selective protein kinase C (PKC) inhibitor, widely recognized for its utility in biochemical and pharmacological research. This compound is critical for studying intracellular signaling pathways, cellular differentiation, and apoptosis, providing researchers with a reliable tool for modulating PKC activity. It is primarily utilized by scientists and R&D professionals in the pharmaceutical, biotechnology, and academic sectors for drug discovery and mechanistic studies.

Application

• Biochemical Research: As a selective inhibitor for studying the role of Protein Kinase C isoforms in signal transduction pathways.
• Pharmacological Studies: Used in vitro and in vivo to investigate the effects of PKC inhibition on cell proliferation, differentiation, and programmed cell death (apoptosis).
• Drug Discovery & Development: Serves as a key reference compound and pharmacological tool in screening assays and target validation for oncology and neurological disorders.
• Academic Research: Employed in university and institutional labs for fundamental research into cellular mechanisms and second messenger systems.
• Biotechnology Applications: Used in the development of cell-based assays and high-throughput screening (HTS) platforms.

Basic Information

Product Name	Ro 32-0432 Hydrochloride
CAS No.	1781828-85-0
Molecular Formula	C27H30ClN3O4 • HCl
Molecular Weight	524.46 g/mol (for free base: 488.00 g/mol)
Synonyms	Ro 32-0432 HCl; 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride; PKC Inhibitor Ro 32-0432; Ro-32-0432; Ro320432; 2,5-Pyrrolidinedione, 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our Ro 32-0432 Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet general research-grade standards, we can discuss custom synthesis and purification to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.