Description

4,5-Difluoro-2,3-Dihydro-1H-Isoindole is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a fused isoindoline ring system with strategic fluorine substitutions, makes it a critical intermediate for developing novel pharmaceutical compounds and functional materials. This compound is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoro-substituted isoindole scaffold can enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Employed in the creation of novel nitrogen-containing ligands for transition metal catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science: Acts as a monomer or building block for synthesizing specialty polymers, dyes, and organic electronic materials with tailored optoelectronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent tags, molecular probes, and bio-conjugation reagents for diagnostic and research applications.

Basic Information

Product Name	4,5-Difluoro-2,3-Dihydro-1H-Isoindole
CAS No.	1781137-89-0
Molecular Formula	C8H7F2N
Molecular Weight	155.15 g/mol
Synonyms	4,5-Difluoro-2,3-dihydro-1H-isoindole; 4,5-Difluoro-isoindoline; 4,5-Difluoro-1H-isoindole, 2,3-dihydro-; 2,3-Dihydro-4,5-difluoro-1H-isoindole; 4,5-Difluoroisoindoline; 1H-Isoindole, 2,3-dihydro-4,5-difluoro-
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2,3-Dihydro-1H-Isoindole is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.