Description

1-Bromo-3-Chloro-5-Fluoro-2-Methyl-Benzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the halogen and methyl groups influence bioactivity and stability.
• Liquid Crystal & OLED Materials: Acts as a building block for advanced electronic materials, where the specific halogen atoms help fine-tune molecular polarity and luminescent properties.
• Cross-Coupling Reactions: An excellent substrate for various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig) due to the reactive bromo and chloro substituents.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for catalysis and molecular recognition studies.
• Polymer Modification: Used to introduce halogenated aromatic units into polymer backbones to alter thermal stability, flame retardancy, or optical characteristics.

Basic Information

Product Name	1-Bromo-3-Chloro-5-Fluoro-2-Methyl-Benzene
CAS No.	1780876-62-1
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	2-Bromo-6-Chloro-4-Fluoro-3-Methylbenzene; 3-Bromo-1-Chloro-5-Fluoro-2-Methylbenzene; Benzene, 1-bromo-3-chloro-5-fluoro-2-methyl-; 2-Methyl-3-bromo-1-chloro-5-fluorobenzene; 1-Bromo-3-chloro-5-fluoro-2-methylbenzene; Bromochlorofluoromethylbenzene (mixed isomer designation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-5-Fluoro-2-Methyl-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.