Description

4,4-Difluoropyrrolidine-3-Carboxylic Acid Hydrochloride(Wxfc0858S1) is a high-purity fluorinated pyrrolidine derivative, serving as a critical building block in modern pharmaceutical and agrochemical research. Its value lies in the unique reactivity and metabolic stability imparted by the difluoro motif, enabling the synthesis of novel bioactive compounds. This advanced intermediate is essential for medicinal chemists and process development scientists working in drug discovery, particularly for the development of protease inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and enzyme modulators.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Development: Serves as a precursor in the creation of advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Bioconjugation & Probe Synthesis: Utilized for labeling and modifying biomolecules in biochemical research and diagnostic development.
• Material Science: Potential application in the synthesis of specialty polymers and advanced materials with unique fluorinated properties.

Basic Information

Product Name	4,4-Difluoropyrrolidine-3-Carboxylic Acid Hydrochloride(Wxfc0858S1)
CAS No.	1779788-81-6
Molecular Formula	C5H8F2NO2 • HCl
Molecular Weight	187.58 (Free base) / 224.04 (HCl salt)
Synonyms	4,4-Difluoro-3-pyrrolidinecarboxylic acid hydrochloride; 3-Carboxy-4,4-difluoropyrrolidine hydrochloride; 4,4-Difluoropyrrolidine-3-carboxylic acid HCl; 1779788-81-6; Wxfc0858S1; 4,4-Difluoroproline hydrochloride (derivative); (3S)-4,4-Difluoropyrrolidine-3-carboxylic acid hydrochloride (if applicable); 3-Pyrrolidinecarboxylic acid, 4,4-difluoro-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 4,4-Difluoropyrrolidine-3-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.