Description

3-Fluoro-2-(Piperidin-4-Yloxy)Pyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique molecular structure, which incorporates both a fluorinated pyridine ring and a piperidine moiety, making it a critical component in modern medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly in kinase inhibitor programs.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its fluorine atom and heterocyclic scaffold.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Agrochemical Research: Employed in the discovery and development of new herbicides, fungicides, or insecticides.
• Chemical Biology Probes: Useful for creating labeled compounds or probes to study biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	3-Fluoro-2-(Piperidin-4-Yloxy)Pyridine Hydrochloride
CAS No.	1779126-87-2
Molecular Formula	C10H14FN2O·HCl
Molecular Weight	232.69 g/mol (Free base: 196.23 g/mol)
Synonyms	3-Fluoro-2-(4-piperidinyloxy)pyridine hydrochloride; 2-(Piperidin-4-yloxy)-3-fluoropyridine hydrochloride; 3-Fluoro-2-(piperidin-4-yloxy)pyridine HCl; 4-((3-Fluoropyridin-2-yl)oxy)piperidine hydrochloride; 1779126-87-2; 3-Fluoro-2-(4-piperidyloxy)pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-(Piperidin-4-Yloxy)Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.