Description

5-[(4-[1,1'-Biphenyl]-4-Yl-1,6-Dihydro-6-Oxo-2-Pyrimidinyl)Thio]-n-Hydroxypentanamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its role as a critical building block in the research and development of novel therapeutic agents, particularly in targeted drug discovery. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for synthesizing potential drug candidates, especially in oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates for targeted therapies.
• Biochemical Research: Used in academic and industrial research to study enzyme inhibition and signal transduction pathways.
• Protease Inhibitor Development: Serves as a core scaffold for developing inhibitors targeting specific proteases involved in disease mechanisms.
• Kinase Inhibitor Synthesis: Employed in the construction of potential kinase inhibitors for cancer and autoimmune disease research.
• High-Throughput Screening (HTS): Utilized as a reference compound or building block in compound libraries for drug discovery screening.
• Custom Synthesis: Provides a versatile starting point for contract research organizations (CROs) and CDMOs performing custom synthesis for clients.

Basic Information

Product Name	5-[(4-[1,1'-Biphenyl]-4-Yl-1,6-Dihydro-6-Oxo-2-Pyrimidinyl)Thio]-n-Hydroxypentanamide
CAS No.	1776116-74-5
Molecular Formula	C27H23N3O3S
Molecular Weight	469.55 g/mol
Synonyms	5-[(4-(Biphenyl-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio]-N-hydroxypentanamide; Biphenyl-pyrimidinone hydroxamic acid derivative; CAS 1776116-74-5; 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide; Hydroxamic acid-based pyrimidinone; HDAC inhibitor intermediate (potential); Biphenyl-linked pyrimidinone thioether.
EINECS	Contact for details

Quality Control

Our 5-[(4-[1,1'-Biphenyl]-4-Yl-1,6-Dihydro-6-Oxo-2-Pyrimidinyl)Thio]-n-Hydroxypentanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.