Description

5-Fluoro-2-(Piperidin-3-Yloxy)Pyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct molecular architecture. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	5-Fluoro-2-(Piperidin-3-Yloxy)Pyridine Hydrochloride
CAS No.	1774897-18-5
Molecular Formula	C11H16ClFN2O
Molecular Weight	246.71 g/mol
Synonyms	5-Fluoro-2-((3-piperidinyl)oxy)pyridine hydrochloride; 2-((Piperidin-3-yl)oxy)-5-fluoropyridine hydrochloride; 3-((5-Fluoropyridin-2-yl)oxy)piperidine hydrochloride; 5-Fluoro-2-(3-piperidinyloxy)pyridine HCl; 5-Fluoro-2-(piperidin-3-yloxy)pyridine HCl salt
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Piperidin-3-Yloxy)Pyridine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.