Description

(2'S, 3'R)-Cabazitaxel CAS NO 1714967-27-7 is a specific stereoisomer of the potent semi-synthetic taxane derivative, Cabazitaxel. This compound is of significant interest in advanced pharmaceutical research and development due to its distinct structural configuration, which can influence biological activity and metabolic pathways. It is primarily required by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery, metabolite studies, and the development of novel chemotherapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a critical high-purity standard for analytical method development, validation, and quality control of cabazitaxel-based drug products and intermediates.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical and clinical research to investigate the efficacy, pharmacokinetics, and safety profile of specific cabazitaxel stereoisomers.
• Metabolite Identification & Synthesis: Essential for the synthesis and study of cabazitaxel metabolites to understand drug metabolism and potential drug-drug interactions.
• Process Chemistry & Impurity Profiling: Employed in the development and optimization of synthetic routes for cabazitaxel and for characterizing isomeric impurities.
• Oncology Drug Discovery: Acts as a key intermediate or building block in the design and synthesis of next-generation taxane derivatives with improved therapeutic indices.
• Regulatory Submissions: Provides well-characterized material for inclusion in regulatory filings (e.g., FDA, EMA) to support drug approval processes.

Basic Information

Product Name	(2'S, 3'R)-Cabazitaxel
CAS No.	1714967-27-7
Molecular Formula	C45H57NO14
Molecular Weight	835.93 g/mol
Synonyms	(2'α,3'β)-Cabazitaxel; Cabazitaxel Stereoisomer; (2'S,3'R)-Cabazitaxel; XRP6258 Stereoisomer; (2'R,3'S)-Cabazitaxel (enantiomer); Jevtana Stereoisomer; Taxoid Derivative; (2'S,3'R)-4α-Acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β,10β-trihydroxy-9-oxo-11-taxen-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate
EINECS	Contact for details

Quality Control

Our (2'S, 3'R)-Cabazitaxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. The material is light-sensitive and easily oxidized; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.