Description

I-Brd9 CAS NO 1714146-59-4 is a potent and selective small molecule inhibitor of the bromodomain and extra-terminal (BET) family of proteins, specifically targeting the second bromodomain (BD2). This compound is a critical research tool for investigating epigenetic regulation and gene expression in various disease models. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, immunology, and inflammatory disease research.

Application

• Epigenetics Research: A key chemical probe for studying BET protein function, chromatin remodeling, and transcriptional regulation.
• Oncology Studies: Used in vitro and in vivo to investigate the role of BRD9 in cancer cell proliferation, survival, and tumor progression.
• Immunology & Inflammation: Applied in research models to understand the modulation of immune cell function and inflammatory pathways.
• Chemical Biology: Serves as a reference standard and a starting point for structure-activity relationship (SAR) studies in drug discovery programs.
• High-Throughput Screening (HTS): Used as a control compound in assays designed to identify novel BET inhibitors or understand off-target effects.

Basic Information

Product Name	I-Brd9
CAS No.	1714146-59-4
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	I-BRD9; IBRD9; BRD9 Inhibitor I; (R)-N-(4-(2-(4-Chlorophenyl)-2-methyl-1,3-dioxolan-2-yl)phenyl)-2-methyl-2H-indazole-5-carboxamide; GSK 503; GSK503; 1,3-Dioxolane, 2-(4-(2-methyl-2H-indazole-5-carboxamido)phenyl)-2-(4-chlorophenyl)-, (2R)-; BRD9 BD2 Inhibitor
EINECS	Contact for details

Quality Control

Our I-Brd9 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.