Description

Fgfr4-In-1 is a potent and selective small molecule inhibitor targeting the Fibroblast Growth Factor Receptor 4 (FGFR4), a key protein implicated in cellular signaling pathways. This compound is crucial for researchers and pharmaceutical developers investigating targeted cancer therapies, particularly for cancers driven by FGFR4 dysregulation, such as hepatocellular carcinoma. It serves as an essential biochemical tool for high-throughput screening, mechanism of action studies, and preclinical drug discovery programs in oncology research.

Application

• Oncology Research & Drug Discovery: Primary tool compound for studying FGFR4 signaling pathways and validating FGFR4 as a therapeutic target in various cancer models.
• Biochemical Assay Development: Used as a reference standard in developing and optimizing high-throughput screening (HTS) assays for FGFR4 inhibitor discovery.
• Cell-Based Studies: Employed in in vitro experiments to assess the effects of FGFR4 inhibition on cell proliferation, apoptosis, and migration in relevant cancer cell lines.
• Preclinical Pharmacology: Supports pharmacokinetic/pharmacodynamic (PK/PD) studies and efficacy testing in animal models of FGFR4-dependent cancers.
• Mechanism of Action (MoA) Research: Aids in elucidating the downstream effects and resistance mechanisms associated with FGFR4 inhibition.
• Chemical Probe for Target Validation: Provides a selective means to probe the biological function of FGFR4 in complex cellular and physiological contexts.

Basic Information

Product Name	Fgfr4-In-1
CAS No.	1708971-72-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FGFR4-IN-1; Fgfr4 Inhibitor 1; 1708971-72-5; FGFR4 Inhibitor; Fibroblast Growth Factor Receptor 4 Inhibitor; FGFR4 tyrosine kinase inhibitor; Research compound 1708971-72-5
EINECS	Contact for details

Quality Control

Our Fgfr4-In-1 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.