Description

4-(Difluoromethoxy)Picolinic Acid is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a difluoromethoxy substituent on the picolinic acid scaffold, makes it an essential intermediate for developing novel active compounds. This product is primarily targeted at research and development teams within the pharmaceutical and agrochemical industries seeking to incorporate fluorine chemistry for enhanced molecular properties.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors or other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group can improve metabolic stability and bioactivity.
• Ligand Precursor: Serves as a starting material for synthesizing specialized chelating ligands used in catalysis and material science.
• Chemical Research: A valuable reagent for academic and industrial research exploring fluorination effects and structure-activity relationships (SAR).
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value fluorinated organic compounds.

Basic Information

Product Name	4-(Difluoromethoxy)Picolinic Acid
CAS No.	1707365-38-5
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	4-(Difluoromethoxy)pyridine-2-carboxylic acid; Picolinic acid, 4-(difluoromethoxy)-; 2-Pyridinecarboxylic acid, 4-(difluoromethoxy)-; 4-DFMPA; 4-(Difluoromethoxy)-2-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Picolinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, guaranteeing traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.