Description

Pf-543 CAS NO 1706522-79-3 is a high-purity, small molecule chemical compound primarily utilized as a potent and selective inhibitor of sphingosine kinase 1 (SphK1). This targeted activity makes it a critical research tool for investigating the role of sphingosine-1-phosphate (S1P) signaling pathways in cellular processes. It is essential for researchers and developers in the life sciences sector, particularly those focused on oncology, immunology, and inflammatory disease research. The compound's specific mechanism of action provides valuable insights for drug discovery and biochemical pathway analysis.

Application

• Biochemical Research: Used as a selective SphK1 inhibitor to study sphingolipid metabolism and S1P-mediated signaling in cell culture models.
• Drug Discovery & Development: Serves as a key pharmacological tool for validating SphK1 as a therapeutic target in preclinical studies for cancer and inflammatory diseases.
• Academic Research: Employed in university and institutional labs to explore the fundamental biology of cell proliferation, survival, and migration.
• Target Validation: Critical for establishing the functional role of SphK1 in specific disease models, aiding in the identification of new drug candidates.
• In Vitro Diagnostics Development: Can be used in assay development to screen for novel SphK1 inhibitors or modulators.

Basic Information

Product Name	Pf-543
CAS No.	1706522-79-3
Molecular Formula	C₂₁H₂₀N₄O₂
Molecular Weight	360.41 g/mol
Synonyms	PF543; PF-543; 2-(p-Hydroxyanilino)-4-(p-hydroxyphenyl)thiazole; Sphingosine Kinase 1 Inhibitor, PF-543; (R)-2-(3,4-Dihydroxyphenyl)-4-[(1E)-3-(4-hydroxyphenyl)prop-2-enoyl]-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one (IUPAC-like); SK1 Inhibitor PF543; SphK1 Inhibitor II
EINECS	Contact for details

Quality Control

Our Pf-543 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.