Description

4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzenesulfonylchloride is a high-purity, multi-functional sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique trifluoromethyl and fluoro substituents, which are essential for modulating the physicochemical properties of target molecules, such as metabolic stability, lipophilicity, and binding affinity. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science: Building block for creating specialty polymers, liquid crystals, and advanced materials with specific surface properties.
• Chemical Research: Versatile reagent in academic and industrial R&D for exploring new reaction pathways and creating compound libraries.
• Dye & Pigment Industry: Intermediate in the production of specialized dyes and pigments requiring sulfonyl chloride chemistry.

Basic Information

Product Name	4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzenesulfonylchloride
CAS No.	1706458-75-4
Molecular Formula	C8H5ClF4O2S
Molecular Weight	276.64 g/mol
Synonyms	4-Fluoro-3-methyl-5-(trifluoromethyl)benzenesulfonyl chloride; 2-Fluoro-6-methyl-4-(trifluoromethyl)benzenesulfonyl chloride; 4-Fluoro-α,α,α-trifluoro-3-methyl-5-benzenesulfonyl chloride; 5-(Trifluoromethyl)-4-fluoro-3-methylbenzenesulfonyl chloride; 3-Methyl-4-fluoro-5-trifluoromethylbenzenesulfonyl chloride; Benzenesulfonyl chloride, 4-fluoro-3-methyl-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzenesulfonylchloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.