Description

3-Bromo-4-Methoxy-5-(Trifluoromethyl)Benzenesulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its unique structure, featuring bromo, methoxy, and trifluoromethyl substituents on a benzenesulfonyl chloride core, makes it a critical intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients, as well as by specialty chemical manufacturers developing advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing sulfonamide or sulfonate ester moieties into complex molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and other specialty materials requiring specific electronic or steric properties.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and other tools for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl structures.
• Sulfonylation Agent: The reactive sulfonyl chloride group is used to sulfonylate amines, alcohols, and other nucleophiles to form sulfonamides and sulfonate esters.

Basic Information

Item	Detail
Product Name	3-Bromo-4-Methoxy-5-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	1706453-20-4
Molecular Formula	C8H5BrClF3O3S
Molecular Weight	353.54 g/mol
Synonyms	3-Bromo-4-methoxy-5-(trifluoromethyl)benzene-1-sulfonyl chloride; 5-Bromo-2-methoxy-α,α,α-trifluoro-m-toluenesulfonyl chloride; 3-Bromo-4-methoxy-α,α,α-trifluorotoluene-5-sulfonyl chloride; 5-(Trifluoromethyl)-3-bromo-4-methoxybenzenesulfonyl chloride; Benzenesulfonyl chloride, 3-bromo-4-methoxy-5-(trifluoromethyl)-; 3-Br-4-MeO-5-CF3-PhSO2Cl
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Methoxy-5-(Trifluoromethyl)Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality ensures consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.