Description

2-Methoxy-5-(Pentafluorosulfur)Benzenesulfonylchloride is a high-value, multi-functional chemical building block characterized by its unique sulfonyl chloride and pentafluorosulfur substituents. This compound is critical for introducing the pentafluorosulfanyl (SF5) group into target molecules, a moiety prized for its profound impact on lipophilicity, metabolic stability, and overall physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by specialty chemical manufacturers developing advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting CNS disorders and metabolic diseases, where the SF5 group enhances blood-brain barrier penetration and stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the pentafluorosulfanyl group contributes to improved weatherfastness and pesticidal activity.
• Functional Material Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and electronic materials with unique surface properties.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create labeled compounds and probes for studying protein-ligand interactions and metabolic pathways.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical and CDMO companies offering bespoke synthesis services for complex, fluorinated molecules.

Basic Information

Product Name	2-Methoxy-5-(Pentafluorosulfur)Benzenesulfonylchloride
CAS No.	1706447-05-3
Molecular Formula	C7H4ClF5O3S2
Molecular Weight	330.68 g/mol
Synonyms	5-(Pentafluoro-λ6-sulfanyl)-2-methoxybenzenesulfonyl chloride; 2-Methoxy-5-(pentafluorosulfanyl)benzenesulfonyl chloride; 1-Methoxy-4-(pentafluorosulfanyl)benzene-2-sulfonyl chloride; SF5-Aryl Sulfonyl Chloride Intermediate; 4-Methoxy-3-(pentafluorosulfanyl)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Pentafluorosulfur)Benzenesulfonylchloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.