Description

2-Fluoro-5-(Pentafluorosulfur)-Benzenesulfonyl Chloride CAS NO 1706447-01-9 is a highly reactive and versatile organosulfur building block, characterized by its unique combination of fluorine and sulfonyl chloride functional groups. This compound is critical for introducing the pentafluorosulfanyl (SF5) moiety into complex molecules, a group prized for its exceptional lipophilicity, metabolic stability, and electron-withdrawing properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas, leveraging the SF5 group to enhance drug-like properties.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the pentafluorosulfanyl group can improve biological activity and environmental persistence profiles.
• Material Science: Serves as a precursor for advanced polymers, liquid crystals, and electronic materials requiring specific fluorine content and chemical resistance.
• Chemical Synthesis Reagent: Employed in organic synthesis as a sulfonylation agent to create sulfonamides, sulfonate esters, and other sulfur-containing derivatives for further chemical exploration.
• Life Sciences & Diagnostics: Potential use in developing molecular probes, tags, and contrast agents for imaging and diagnostic applications due to its distinct chemical handle.

Basic Information

Product Name	2-Fluoro-5-(Pentafluorosulfur)-Benzenesulfonyl Chloride
CAS No.	1706447-01-9
Molecular Formula	C6H2ClF6O2S2
Molecular Weight	312.66 g/mol
Synonyms	2-Fluoro-5-(pentafluoro-λ6-sulfanyl)benzenesulfonyl chloride; 2-Fluoro-5-(SF5)benzenesulfonyl chloride; 1-Fluoro-4-(pentafluorosulfanyl)-2-sulfonylchloridobenzene; Benzenesulfonyl chloride, 2-fluoro-5-(pentafluorosulfur)-; SF5-Aryl Sulfonyl Chloride Derivative; 2-Fluoro-5-pentafluorosulfanylbenzenesulfonyl chloride; 4-Fluoro-3-(pentafluorosulfanyl)benzenesulfonyl chloride (alternate numbering)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(Pentafluorosulfur)-Benzenesulfonyl Chloride is manufactured and analyzed under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our standard quality commitment includes comprehensive analysis by HPLC, NMR (¹H, ¹⁹F, ¹³C), and mass spectrometry to confirm identity and quantify purity. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment. Specifications can be developed to meet specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) and highly volatile nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.