Description

2-Methoxy-4,6-Bis(Trifluoromethyl)Benzenesulfonylchloride is a specialized organosulfur compound featuring a sulfonyl chloride functional group flanked by electron-withdrawing trifluoromethyl substituents. This molecular architecture makes it a highly reactive and valuable building block in advanced synthetic chemistry, particularly for introducing the sulfonyl moiety under mild conditions. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, sulfonamides, and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for creating sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Material Science: Serves as a precursor for sulfonated polymers and specialty chemicals with unique surface properties.
• Chemical Research: Employed in organic synthesis for C-S bond formation and as a sulfonylating agent in complex molecule construction.
• Ligand and Catalyst Development: Useful for synthesizing specialized ligands and catalysts used in asymmetric synthesis and coupling reactions.

Basic Information

Product Name	2-Methoxy-4,6-Bis(Trifluoromethyl)Benzenesulfonylchloride
CAS No.	1706439-13-5
Molecular Formula	C10H5ClF6O3S
Molecular Weight	366.65 g/mol
Synonyms	2-Methoxy-α,α,α,α',α',α'-hexafluoro-4,6-xylene-α-sulfonyl chloride; 4,6-Bis(trifluoromethyl)-2-methoxybenzenesulfonyl chloride; 2-Methoxy-4,6-bis(trifluoromethyl)benzene-1-sulfonyl chloride; 1-(Chlorosulfonyl)-2-methoxy-4,6-bis(trifluoromethyl)benzene; 4,6-Bis(trifluoromethyl)-2-methoxybenzenesulfonyl chloride; 2-Methoxy-4,6-bis(trifluoromethyl)phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-Methoxy-4,6-Bis(Trifluoromethyl)Benzenesulfonylchloride adheres to stringent in-process controls and final batch analysis to ensure consistent high purity and performance. Each lot is validated against comprehensive specifications using advanced analytical techniques including HPLC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.