Description

2-Fluoro-5-Methyl-3-(Trifluoromethyl)Benzyl Bromide is a high-value, multi-functional benzyl bromide derivative, distinguished by its unique combination of fluorine and bromine substituents. This compound serves as a critical advanced pharmaceutical intermediate and versatile organic synthesis building block, enabling the introduction of complex aromatic motifs into target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science: Employed in the synthesis of monomers and polymers for specialty materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in research due to the reactivity of the benzyl bromide group.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions for clinical trial material production.

Basic Information

Product Name	2-Fluoro-5-Methyl-3-(Trifluoromethyl)Benzyl Bromide
CAS No.	1706438-74-5
Molecular Formula	C10H7BrF4
Molecular Weight	287.06 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-5-methyl-3-(trifluoromethyl)benzene; (2-Fluoro-5-methyl-3-(trifluoromethyl)phenyl)methyl bromide; α-Bromo-2-fluoro-5-methyl-α,α,α-trifluoro-m-xylene; 2-Fluoro-5-methyl-3-trifluoromethylbenzyl bromide; 3-(Bromomethyl)-6-fluoro-α,α,α-trifluoro-m-xylene; Benzene, 1-(bromomethyl)-2-fluoro-5-methyl-3-(trifluoromethyl)-; Bromomethyl derivative of 2-fluoro-5-methyl-3-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methyl-3-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with ICH guidelines, and we support development from research to commercial scale with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.