Description

Pi3Kδ-In-2 is a potent and selective small-molecule inhibitor of the phosphoinositide 3-kinase delta (PI3Kδ) isoform. This compound matters for its critical role in advancing research into B-cell mediated diseases and immune-oncology pathways. Pharmaceutical R&D teams and academic researchers in the fields of immunology and oncology need it for target validation, mechanism-of-action studies, and as a key reference standard in drug discovery programs.

Application

• Biochemical Research: Used as a selective tool compound to study PI3Kδ signaling pathways and validate its role in cellular processes.
• Drug Discovery & Development: Serves as a reference standard and lead compound for developing novel therapeutics targeting PI3Kδ.
• Immunology Studies: Applied in research focused on B-cell activation, proliferation, and survival, relevant to autoimmune and inflammatory diseases.
• Oncology Research: Investigated for its potential in hematological malignancies where PI3Kδ signaling is implicated, such as chronic lymphocytic leukemia (CLL).
• Cellular Assay Development: Utilized as a control inhibitor in high-throughput screening (HTS) and enzyme activity assays.
• Preclinical Pharmacology: Employed in in vitro and in vivo models to assess efficacy and pharmacokinetic properties of PI3Kδ-targeting agents.

Basic Information

Product Name	Pi3Kδ-In-2
CAS No.	1702816-75-8
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	PI3K-delta Inhibitor 2; PI3Kδ Inhibitor 2; 5-(2-(1H-Indazol-5-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-N-methylpyridin-2-amine; (S)-5-(2-(1H-Indazol-5-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)-N-methylpyridin-2-amine; PI3Kδ-IN-2; PI3Kδ In-2; PI3K delta Inhibitor 2
EINECS	Contact for details

Quality Control

Our Pi3Kδ-In-2 is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (1H NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.