Description

Bcrp-In-1 is a potent and selective small-molecule inhibitor of the Breast Cancer Resistance Protein (BCRP/ABCG2). This compound is a critical research tool for investigating multidrug resistance mechanisms in oncology and pharmacokinetics. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of cancer biology and drug metabolism. The high specificity of Bcrp-In-1 makes it invaluable for in vitro and in vivo studies aimed at overcoming transporter-mediated chemoresistance.

Application

• Pharmacology Research: Used as a reference standard and selective inhibitor to study the function and inhibition of the BCRP/ABCG2 efflux transporter.
• Drug-Drug Interaction (DDI) Studies: Employed in preclinical assays to assess the potential for transporter-based interactions in new chemical entities.
• Cancer Research: Applied in cellular models to reverse BCRP-mediated multidrug resistance, enhancing the efficacy of chemotherapeutic agents.
• ADME-Tox Screening: Utilized in absorption, distribution, metabolism, and excretion (ADME) profiling to understand the role of BCRP in drug disposition and toxicity.
• Biochemical Assay Development: Serves as a key control compound in high-throughput screening (HTS) campaigns targeting ABC transporters.
• Academic & Institutional Research: Supports fundamental research into the structure and mechanism of ATP-binding cassette (ABC) transporters.

Basic Information

Product Name	Bcrp-In-1
CAS No.	1699720-85-8
Molecular Formula	C₂₀H₂₀N₄O₂S
Molecular Weight	380.46 g/mol
Synonyms	Bcrp-In-1; BCRP inhibitor 1; ABCG2 Inhibitor (Bcrp-In-1); 3-((3S,4R)-3-((6,7-Dimethoxyquinolin-4-yl)oxy)-1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1,5-naphthyridin-2(1H)-one; Ko143 analog; BCRP/ABCG2 inhibitor; BCRP inhibitor Ko143 derivative
EINECS	Contact for details

Quality Control

Our Bcrp-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducibility and reliability in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.