Description

Nampt-In-1 is a potent and selective small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the NAD+ salvage pathway. This compound is a critical research tool for investigating cellular metabolism, energy homeostasis, and the role of NAMPT in various disease states, including cancer, inflammation, and aging. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in metabolic pathway analysis, oncology research, and drug discovery programs.

Application

• Biochemical Research: Used as a selective probe to study the NAD+ salvage pathway and its impact on cellular metabolism and bioenergetics.
• Oncology Research: Investigated for its potential to inhibit cancer cell proliferation by depleting intracellular NAD+ levels, inducing metabolic stress and apoptosis.
• Inflammation & Immunology Studies: Applied in research exploring the role of NAMPT (visfatin/PBEF) in inflammatory processes and immune cell function.
• Neurodegenerative Disease Models: Utilized in preclinical studies to understand metabolic dysregulation in conditions like Alzheimer's and Parkinson's disease.
• Drug Discovery & Development: Serves as a lead compound or reference standard for developing novel NAMPT-targeted therapeutics.
• Cell Senescence & Aging Research: Employed to examine the link between NAD+ metabolism, sirtuin activity, and cellular aging.

Basic Information

Product Name	Nampt-In-1
CAS No.	1698878-14-6
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	NAMPT Inhibitor FK866 analog; NAMPT-IN-1; (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide; GNE-617 (historical code); 1698878-14-6; NAMPT inhibitor (research grade); Nicotinamide phosphoribosyltransferase inhibitor 1
EINECS	Contact for details

Quality Control

Our Nampt-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC, identity confirmation by mass spectrometry and NMR, and determination of residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption. The product is stable under these conditions for at least two years from the date of receipt.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.