Description

Ccr2 Antagonist 1 CAS NO 1683534-96-4 is a potent and selective small molecule inhibitor of the C-C chemokine receptor type 2 (CCR2), a key target in inflammatory and autoimmune disease pathways. This high-purity compound is essential for pharmaceutical research and development, enabling critical studies in immunology and drug discovery. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in the development of novel therapeutics for conditions such as rheumatoid arthritis, multiple sclerosis, atherosclerosis, and diabetic nephropathy.

Application

• Drug Discovery & Preclinical Research: Serves as a critical reference standard and active pharmacological tool for validating CCR2 as a therapeutic target.
• Inflammation & Immunology Studies: Used in in vitro and in vivo models to investigate the role of CCR2/CCL2 signaling in macrophage migration and inflammatory responses.
• Autoimmune Disease Research: Applied in research focused on rheumatoid arthritis, multiple sclerosis, and psoriasis to assess therapeutic efficacy and mechanism of action.
• Metabolic Disorder Research: Utilized in studies exploring the link between inflammation, insulin resistance, and conditions like type 2 diabetes and non-alcoholic steatohepatitis (NASH).
• Cardiovascular Disease Models: Employed in atherosclerosis research to inhibit monocyte recruitment to arterial plaques.
• Oncology Research: Investigated for its potential to modulate the tumor microenvironment by affecting tumor-associated macrophages (TAMs).
• Biochemical Assay Development: Acts as a key component in high-throughput screening (HTS) campaigns and binding assays to identify new CCR2 antagonists.

Basic Information

Product Name	Ccr2 Antagonist 1
CAS No.	1683534-96-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CCR2 Antagonist 1; (S)-2-(4-Chlorophenyl)-N-((1-(4-fluorobenzyl)piperidin-4-yl)methyl)-1-(4-fluorophenyl)-5-methyl-1H-pyrrole-3-carboxamide; BMS-741672; BMS 741672; BMS741672; CCR2 antagonist BMS-741672
EINECS	Contact for details

Quality Control

Our Ccr2 Antagonist 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.