Description

Rodatristat is a potent and selective inhibitor of tryptophan hydroxylase 1 (TPH1), a key enzyme in the biosynthesis of peripheral serotonin. This compound matters for its targeted mechanism of action, which holds significant promise for modulating serotonin levels in peripheral tissues without affecting the central nervous system. It is primarily needed by pharmaceutical research and development organizations focused on developing novel therapeutics for gastrointestinal disorders, carcinoid syndrome, and other serotonin-mediated conditions.

Application

• Pharmaceutical Research & Development: As a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for TPH1-targeted therapies.
• Drug Discovery Programs: Used in high-throughput screening and lead optimization to develop new treatments for serotonin-related pathologies.
• Biochemical Research: A tool compound for studying the role of peripheral serotonin in physiology and disease models, including inflammatory bowel disease (IBD) and fibrosis.
• Oncology Research: Investigation into the role of serotonin in tumor microenvironment and carcinoid syndrome management.
• Metabolic Disorder Studies: Research into the connection between gut-derived serotonin, metabolism, and bone formation.
• GMP Manufacturing: Sourcing of high-purity material for the production of clinical trial supplies and eventual commercial drug products.

Basic Information

Product Name	Rodatristat
CAS No.	1673571-51-1
Molecular Formula	C24H24F3N5O3
Molecular Weight	487.47 g/mol
Synonyms	Rodatristat ethyl; (R)-2-Amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid; LX-1031; LX1031; TPH1 Inhibitor LX-1031; (2R)-2-Amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Rodatristat is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Quality is assured through comprehensive analytical testing including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and impurity profiles. We support development with material that meets the stringent standards required for preclinical and clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.