Description

Hif2α-In-2 is a potent and selective small molecule inhibitor of Hypoxia-Inducible Factor 2 Alpha (HIF-2α), a key transcription factor involved in cellular response to low oxygen. This compound matters for researchers and developers as it provides a critical tool for modulating the HIF signaling pathway, which is implicated in various disease states including cancer and inflammatory disorders. It is needed by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on oncology, metabolic disease, and novel therapeutic target validation.

Application

• Biochemical Research: Used as a reference standard and probe compound in studies investigating the role of HIF-2α in cellular physiology and pathology.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool for screening and developing novel therapeutics targeting the HIF pathway.
• Oncology Research: Applied in in vitro and in vivo models to study tumor angiogenesis, metastasis, and cell survival under hypoxic conditions.
• Mechanistic Studies: Utilized to dissect the specific contributions of HIF-2α versus HIF-1α in complex biological processes and disease models.
• High-Throughput Screening (HTS): Employed in assay development and as a control in HTS campaigns to identify new modulators of hypoxia signaling.

Basic Information

Product Name	Hif2α-In-2
CAS No.	1672666-82-8
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	HIF-2α Inhibitor 2; HIF2A Inhibitor 2; 2-[[4-[[3-(Methoxycarbonyl)phenyl]carbamoyl]phenyl]methyl]-3-methyl-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ium-1-olate; PT2385 analog; HIF2α antagonist; PT2399 related compound; Hypoxia-inducible factor 2-alpha inhibitor
EINECS	Contact for details

Quality Control

Our Hif2α-In-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.