Description

Yap-Tead Inhibitor 1 CAS NO 1659305-78-8 is a potent and selective small molecule inhibitor targeting the Yap/Tead transcriptional complex, a key signaling node in the Hippo pathway. This compound is critical for disrupting aberrant cell proliferation and is a valuable tool for oncology research and drug discovery. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel cancer therapeutics and studying cellular signaling mechanisms.

Application

• Oncology Research: Investigation of Hippo pathway signaling and its role in tumorigenesis, cancer cell proliferation, and metastasis.
• Drug Discovery & Development: Serving as a lead compound or pharmacological tool for developing novel anti-cancer therapeutics targeting Yap/Tead protein-protein interactions.
• Mechanistic Studies: Elucidating the biological functions of Yap and Tead transcription factors in cell fate determination, organ size control, and tissue regeneration.
• High-Throughput Screening (HTS): Used as a reference standard or positive control in assays designed to identify new Yap/Tead pathway inhibitors.
• Biochemical Assays: In vitro evaluation of compound potency and selectivity in fluorescence polarization (FP), time-resolved fluorescence resonance energy transfer (TR-FRET), or reporter gene assays.
• Preclinical Studies: Evaluation of efficacy and pharmacokinetic properties in relevant cell-based and animal models of cancer.

Basic Information

Product Name	Yap-Tead Inhibitor 1
CAS No.	1659305-78-8
Molecular Formula	C₂₉H₂₈N₄O₃
Molecular Weight	480.56 g/mol
Synonyms	YAP-TEAD Inhibitor 1; Verteporfin analog; Hippo Pathway Inhibitor; TEAD Inhibitor; YAP/TAZ Inhibitor; 4-[(4-Phenoxyphenyl)sulfonyl]phenol derivative; (E)-2-[(4-Phenoxyphenyl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]ethenesulfonamide (related structural analog); Compound 1 (Yap-Tead).
EINECS	Contact for details

Quality Control

Our Yap-Tead Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.