Description

1-(Bromomethyl)-4-(1,1-Difluoroethyl)-Benzene is a high-value, multi-functional aromatic building block featuring both a reactive benzyl bromide group and a difluoroethyl moiety. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where fluorine substitution is desired to modulate properties like metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and CNS-active compounds where the difluoroethyl group enhances pharmacokinetic properties.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine atoms to improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic display materials and organic light-emitting diodes (OLEDs), where fluorine substitution fine-tunes electronic characteristics and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing properties such as chemical resistance, low surface energy, and optical clarity for specialty coatings and films.
• Cross-Coupling Reactions: The benzyl bromide moiety acts as an efficient electrophile in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Radiolabeling Precursor: Potential use as a synthon for introducing radioactive isotopes (e.g., Fluorine-18) for positron emission tomography (PET) tracer development in diagnostic imaging.

Basic Information

Product Name	1-(Bromomethyl)-4-(1,1-Difluoroethyl)-Benzene
CAS No.	1654773-79-1
Molecular Formula	C9H9BrF2
Molecular Weight	235.07 g/mol
Synonyms	4-(1,1-Difluoroethyl)benzyl Bromide; α-Bromo-4-(1,1-difluoroethyl)toluene; 1-Bromomethyl-4-(1,1-difluoroethyl)benzene; p-(1,1-Difluoroethyl)benzyl Bromide; (4-(1,1-Difluoroethyl)phenyl)methyl Bromide; [4-(1,1-Difluoroethyl)phenyl]methyl Bromide; 1654773-79-1 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-4-(1,1-Difluoroethyl)-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.