Description

Gsk484 CAS NO 1652591-81-5 is a high-purity, small molecule chemical compound of significant interest in pharmaceutical and biochemical research. This compound serves as a potent and selective inhibitor of the PRMT5 enzyme, a key regulator of cellular processes. It is primarily utilized by researchers and development teams in the life sciences sector for target validation, mechanism-of-action studies, and early-stage drug discovery. Our supply ensures consistent quality and reliable availability for critical R&D applications.

Application

• Biochemical Research: Used as a selective tool compound for studying protein arginine methyltransferase 5 (PRMT5) activity and function in cellular pathways.
• Oncology Research: Investigated in preclinical studies for its potential role in modulating cancer cell proliferation and survival, particularly in hematological and solid tumor models.
• Epigenetics & Gene Regulation: Applied in research focused on histone methylation, gene expression regulation, and epigenetic mechanisms.
• Pharmaceutical Development: Serves as a reference standard and a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutic agents.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental biological studies and publication-related work.
• Contract Research Organizations (CROs): Used in high-throughput screening (HTS) and specialized assay development services for client projects.

Basic Information

Product Name	Gsk484
CAS No.	1652591-81-5
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	GSK484; PRMT5 Inhibitor GSK484; 4-[[4-[[(3S)-3-Amino-3-carboxypropyl]amino]-6-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3,5-triazin-2-yl]amino]benzoic acid; (S)-4-((4-((4-Amino-4-carboxybutyl)amino)-6-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3,5-triazin-2-yl)amino)benzoic acid; GSK-484; GSK 484; CAS 1652591-81-5
EINECS	Contact for details

Quality Control

Our Gsk484 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.