Description

2-(Difluoromethyl)-5-Nitropyridine is a high-value, multi-functional heterocyclic building block characterized by its difluoromethyl and nitro substituents. This compound is essential for facilitating late-stage functionalization and introducing fluorine atoms into complex molecular architectures, a critical strategy in modern drug discovery. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Fluorine Chemistry: An important reagent for introducing fluorine motifs in organic synthesis, enabling the study of structure-activity relationships (SAR).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting custom synthesis and scale-up projects for global clients.

Basic Information

Product Name	2-(Difluoromethyl)-5-Nitropyridine
CAS No.	1646152-46-6
Molecular Formula	C6H4F2N2O2
Molecular Weight	174.11 g/mol
Synonyms	5-Nitro-2-(difluoromethyl)pyridine; 2-Difluoromethyl-5-nitropyridine; Pyridine, 2-(difluoromethyl)-5-nitro-; 1646152-46-6
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethyl)-5-Nitropyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and MS, is available for each lot to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the nitro and heterocyclic nature of the compound, it should be handled as moisture-sensitive.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.