Description

O6-(2-Hydroxyethyl-D4)-2'-Deoxyguanosine is a deuterated analog of a key DNA nucleoside, specifically modified at the O6 position of the guanine base. This compound is essential as a high-purity internal standard and reference material in quantitative mass spectrometry-based analyses, ensuring precise and accurate measurement of DNA adducts. It is critically needed by researchers and quality control laboratories in the fields of toxicology, biomarker discovery, pharmaceutical development, and forensic science where the detection and quantification of specific DNA modifications are paramount.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the accurate quantification of O6-(2-hydroxyethyl)-2'-deoxyguanosine and related adducts in biological matrices.
• Biomarker Research: Enables precise studies on DNA damage and repair mechanisms, particularly related to exposure to alkylating agents and ethylene oxide.
• Toxicology and Carcinogenesis Studies: Used in research to understand the formation and persistence of specific DNA adducts as markers of genotoxic exposure.
• Pharmaceutical Metabolism Studies: Supports ADME (Absorption, Distribution, Metabolism, Excretion) research for drugs that may form similar DNA adducts.
• Forensic and Environmental Analysis: Aids in the detection of exposure to specific chemicals in forensic toxicology and environmental health monitoring.
• Method Development and Validation: Critical for developing and validating highly sensitive and specific analytical methods in regulated bioanalytical laboratories.
• Quality Control Reference: Serves as a certified reference material to ensure the reliability and consistency of analytical testing in contract research organizations (CROs).

Basic Information

Product Name	O6-(2-Hydroxyethyl-D4)-2'-Deoxyguanosine
CAS No.	1644566-69-7
Molecular Formula	C₁₂H₁₃D₄N₅O₅
Molecular Weight	299.29 g/mol
Synonyms	O6-(2-Hydroxyethyl-d4)-2'-deoxyguanosine; 2'-Deoxy-O6-(2-hydroxyethyl-d4)guanosine; Deuterated O6-HEG; O6-(2-Hydroxyethyl-1,1,2,2-d4)-2'-deoxyguanosine; dG-HE-d4; Stable Isotope Labeled dG Adduct; [D4]-O6-(2-Hydroxyethyl)-2'-deoxyguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[(1,1,2,2-tetradeuterio-2-hydroxyethyl)amino]-1H-purin-2-one
EINECS	Contact for details

Quality Control

Our O6-(2-Hydroxyethyl-D4)-2'-Deoxyguanosine is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.