Description

Jnk-In-8 is a potent and selective small molecule inhibitor of c-Jun N-terminal kinase (JNK), a key enzyme involved in cellular stress response pathways. This high-purity biochemical tool is essential for researchers investigating the role of JNK signaling in apoptosis, inflammation, and various disease models. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, neurodegenerative disorders, and metabolic disease research.

Application

• Biochemical Research: Used as a selective inhibitor to study JNK-mediated signal transduction pathways in cell-based assays.
• Drug Discovery & Development: Serves as a key pharmacological tool for target validation and lead compound optimization in therapeutic areas like cancer and inflammation.
• Academic Research: Facilitates fundamental studies on cellular stress responses, programmed cell death (apoptosis), and gene expression regulation.
• Disease Modeling: Employed in creating in vitro models to understand the pathogenesis of conditions such as Parkinson's disease, diabetes, and ischemic injury.
• High-Throughput Screening (HTS): Acts as a reference compound or control in screening campaigns to identify novel JNK modulators.

Basic Information

Product Name	Jnk-In-8
CAS No.	1644498-56-5
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	JNK-IN-8; JNK Inhibitor VIII; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole; (4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-5-(pyridin-4-yl)-1H-imidazole); JNK Inhibitor 8; c-Jun N-terminal Kinase Inhibitor VIII
EINECS	Contact for details

Quality Control

Every batch of Jnk-In-8 is manufactured under strict quality management protocols and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for high-grade research chemicals, supporting reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.