Description

3-Indoxyl Sulfate-D5 Potassium Salt is a stable isotope-labeled internal standard critical for quantitative mass spectrometry analysis. This deuterated compound is essential for ensuring analytical accuracy and precision in complex biological matrices. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for metabolomics studies and biomarker validation.

Application

• Internal Standard for LC-MS/MS: Used for the precise quantification of indoxyl sulfate, a key uremic toxin, in biological samples like plasma, serum, and urine.
• Metabolomics Research: Enables accurate profiling of tryptophan metabolism pathways in studies related to chronic kidney disease (CKD), cardiovascular health, and gut microbiome interactions.
• Biomarker Assay Development: Serves as a critical reference standard in the development and validation of clinical diagnostic assays for renal function and toxicity.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Facilitates the accurate measurement of drug-induced changes in endogenous metabolite levels during preclinical and clinical trials.
• Quality Control in Reference Material Production: Employed in the manufacture and certification of certified reference materials (CRMs) for clinical chemistry.

Basic Information

Product Name	3-Indoxyl Sulfate-D5 Potassium Salt
CAS No.	1644451-34-2
Molecular Formula	C8D5H3KO4S
Molecular Weight	256.33 g/mol (approx.)
Synonyms	Indoxyl Sulfate-d5 Potassium Salt; 3-Indoxyl Sulfate Potassium Salt-d5; Indican-d5 Potassium Salt; 1H-Indol-3-yl Sulfate-d5 Potassium Salt; Potassium 1H-Indol-3-yl Sulfate-d5; IS-d5 (Internal Standard); Deuterated Indoxyl Sulfate Potassium Salt; Uremic Toxin-d5 Internal Standard
EINECS	Contact for details

Quality Control

Every batch of 3-Indoxyl Sulfate-D5 Potassium Salt is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed via NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA), including batch-specific data on purity, isotopic enrichment, and residual solvents, is provided to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.