Description

Gw406108X is a high-purity, non-steroidal synthetic compound identified by CAS NO 1644443-92-4. This specialized chemical is valued for its role as a potent and selective research tool in biochemical and pharmacological studies. It is primarily utilized by research institutions and pharmaceutical development companies engaged in advanced life science research and drug discovery programs.

Application

• Biochemical Research: Used as a potent and selective FXR (Farnesoid X Receptor) agonist for investigating bile acid metabolism, cholesterol homeostasis, and liver function pathways.
• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of novel therapeutics for metabolic and liver diseases.
• In Vitro Studies: Employed in cell-based assays and high-throughput screening (HTS) to study receptor activation, gene expression, and downstream signaling effects.
• Preclinical Research: Utilized in animal model studies to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of FXR-targeted drug candidates.
• Mechanism of Action Studies: Acts as a critical tool compound for elucidating the complex roles of FXR in inflammation, fibrosis, and cancer biology.

Basic Information

Product Name	Gw406108X
CAS No.	1644443-92-4
Molecular Formula	C31H34N2O5S
Molecular Weight	546.68 g/mol
Synonyms	GW4064; GW-4064; 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic Acid; Fexaramine; FXR Agonist GW4064; GSK8062; GW 4064; 6-ECDCA; 6α-Ethylchenodeoxycholic Acid (common analog reference)
EINECS	Contact for details

Quality Control

Every batch of Gw406108X is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing results from HPLC, NMR, and MS analyses. Our quality commitment aligns with standards expected for research-grade and pharmaceutical intermediate materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.