Description

Acid Ceramidase Inhibitor 17A is a potent and selective small molecule inhibitor of the lysosomal enzyme acid ceramidase (AC). This compound matters because it serves as a critical research tool for modulating ceramide metabolism, a key pathway involved in cellular signaling, apoptosis, and disease progression. It is primarily needed by researchers and pharmaceutical developers in the fields of oncology, dermatology, and metabolic disease research for target validation and therapeutic discovery.

Application

• Biomedical Research: Fundamental tool for studying the role of acid ceramidase and ceramide signaling in cellular processes like apoptosis, autophagy, and senescence.
• Oncology Research: Investigation of potential cancer therapeutics, as ceramide metabolism is often dysregulated in tumors, affecting cell survival and drug resistance.
• Dermatology & Skin Disease Models: Research into conditions like Farber disease, psoriasis, and atopic dermatitis where ceramide levels are implicated.
• Inflammatory Disease Studies: Exploration of the enzyme's role in inflammatory pathways and immune cell function.
• Drug Discovery & Preclinical Development: Used as a reference compound or lead molecule in high-throughput screening and hit-to-lead optimization campaigns.
• Cell Biology & Biochemistry: Mechanistic studies to dissect sphingolipid metabolism and its impact on cellular homeostasis.

Basic Information

Product Name	Acid Ceramidase Inhibitor 17A
CAS No.	1644158-57-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	AC Inhibitor 17A; Ceramidase Inhibitor 17A; ACi 17A; N-[(1S)-1-(3-Chlorophenyl)-2-[(2,4-dichlorophenyl)methylamino]ethyl]-2,4-dichlorobenzamide; B13; LCL-521; Acid Ceramidase Inhibitor LCL521; Research Compound 1644158-57-5
EINECS	Contact for details

Quality Control

Our Acid Ceramidase Inhibitor 17A is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity verification and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, related substances, and residual solvents. We adhere to high standards suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Store under inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.