Description

Dhodh-In-2 CAS NO 1644156-80-8 is a high-purity, small molecule inhibitor targeting the dihydroorotate dehydrogenase (DHODH) enzyme, a key component in the *de novo* pyrimidine biosynthesis pathway. This compound is of significant value for research and development in life sciences, offering a precise tool for modulating cellular nucleotide pools. It is primarily needed by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in oncology, immunology, and antiviral drug discovery programs.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of the DHODH enzyme in cellular metabolism and proliferation.
• Oncology Research: Investigated for its potential to inhibit the growth of cancer cells by disrupting pyrimidine synthesis, a critical process for rapidly dividing cells.
• Immunology Studies: Employed to explore immune cell function and the development of potential therapies for autoimmune diseases.
• Antiviral Drug Discovery: Evaluated for activity against viruses that are dependent on host cell pyrimidine biosynthesis for replication.
• Mechanism of Action (MOA) Studies: Serves as a reference compound for validating assays and understanding signaling pathways dependent on DHODH.
• Preclinical Development: Used in *in vitro* and *in vivo* models to assess pharmacokinetics, efficacy, and safety profiles of DHODH-targeting candidates.

Basic Information

Product Name	Dhodh-In-2
CAS No.	1644156-80-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DHODH Inhibitor 2; Dihydroorotate Dehydrogenase Inhibitor 2; 1644156-80-8; Brequinar analog; Leflunomide related compound; Pyrimidine synthesis inhibitor
EINECS	Contact for details

Quality Control

Our Dhodh-In-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including purity assay and identity confirmation. A Certificate of Analysis (COA) detailing specific results for purity, potency, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.