Description

Fumarate Hydratase-In-1 CAS NO 1644060-37-6 is a potent and selective small molecule inhibitor designed for biochemical and pharmacological research. This compound is of significant interest for its role in modulating fumarate hydratase activity, a key enzyme in the tricarboxylic acid (TCA) cycle. It is primarily utilized by research scientists and pharmaceutical developers in the fields of metabolic disease research, cancer biology, and enzymology to investigate cellular metabolism and identify novel therapeutic pathways.

Application

• Biochemical Research: Used as a tool compound to study the kinetics and inhibition mechanisms of fumarate hydratase (fumarase) in vitro.
• Metabolic Pathway Analysis: Employed in cell-based assays to investigate the consequences of TCA cycle disruption on energy metabolism and redox balance.
• Oncology Research: Applied in research targeting cancers with dysregulated metabolism, such as renal cell carcinoma and hereditary leiomyomatosis.
• Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening campaigns for developing novel metabolic inhibitors.
• Academic & Institutional Studies: Utilized in university and research institute laboratories for fundamental studies in enzymology and cellular bioenergetics.

Basic Information

Product Name	Fumarate Hydratase-In-1
CAS No.	1644060-37-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FH-IN-1; Fumarate Hydratase Inhibitor 1; Fumarase Inhibitor 1; 1644060-37-6; Fumarate Hydratase-In-1 (CAS 1644060-37-6); Fumarase-IN-1
EINECS	Contact for details

Quality Control

Our Fumarate Hydratase-In-1 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized using advanced analytical techniques including NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and strength is provided with each shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The container should be kept in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.