Description

Monoacylglycerol Lipase Inhibitor 21 is a potent and selective small molecule inhibitor of the monoacylglycerol lipase (MAGL) enzyme. This compound is a critical research tool for investigating the endocannabinoid system, specifically the role of 2-arachidonoylglycerol (2-AG) signaling. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic disorders, neurological conditions, and inflammation. The high selectivity of this inhibitor makes it invaluable for target validation and mechanistic studies in preclinical models.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies exploring the physiological and pathological roles of the MAGL enzyme.
• Drug Discovery & Development: Serves as a lead compound or chemical probe for developing novel therapeutics targeting pain, neuroinflammation, and metabolic syndromes.
• Neuroscience Studies: Applied in vitro and in vivo to modulate endocannabinoid tone, aiding research into neurodegenerative diseases, epilepsy, and anxiety.
• Biochemical Assay Development: Employed as a control inhibitor in high-throughput screening (HTS) campaigns and enzymatic activity assays.
• Metabolic Disorder Research: Investigated for its potential effects on energy homeostasis, insulin sensitivity, and lipid metabolism in preclinical models.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in cell biology and signal transduction pathways.

Basic Information

Product Name	Monoacylglycerol Lipase Inhibitor 21
CAS No.	1643657-35-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MAGL Inhibitor 21; Monoacylglycerol Lipase Inhibitor 21; 1643657-35-5; MAGLi 21; Research Compound 1643657-35-5; Selective MAGL Inhibitor; Endocannabinoid System Modulator; Biochemical Inhibitor 1643657
EINECS	Contact for details

Quality Control

Our Monoacylglycerol Lipase Inhibitor 21 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.