Description

Tenalisib is a potent and selective small-molecule inhibitor of the PI3Kδ and PI3Kγ isoforms, representing a significant advancement in targeted therapeutic research. This compound is crucial for investigating novel treatment pathways in oncology and autoimmune disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on developing innovative immunomodulatory and anti-cancer agents.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of novel PI3K inhibitors.
• Oncology Research: For preclinical studies targeting hematological malignancies and solid tumors where PI3Kδ/γ signaling pathways are implicated.
• Immunology & Autoimmune Disease Research: Used in studies exploring treatments for conditions like rheumatoid arthritis, lupus, and other inflammatory diseases.
• Biochemical Assay Development: Serves as a critical tool compound for high-throughput screening (HTS) and mechanism-of-action studies.
• Academic Research: Employed in university and institutional labs for fundamental research on cell signaling, proliferation, and immune cell function.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	Tenalisib
CAS No.	1639417-53-0
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	RP6530; Tenalisib (RP6530); (S)-2-(1-(9H-Purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one; (S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenyl-3,4-dihydroquinazolin-4-one; PI3Kδ/γ Inhibitor (RP6530); RP-6530; Tenalisibum
EINECS	Contact for details

Quality Control

Our Tenalisib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.