Description

σ-1 Receptor Antagonist 1 is a high-purity, small-molecule research chemical designed for precise pharmacological intervention. This compound is a selective antagonist of the σ-1 receptor, a key chaperone protein implicated in cellular stress response and neurological signaling pathways. It is an essential tool for researchers in neuroscience, oncology, and pharmacology, enabling the study of neuropathic pain, neurodegenerative diseases, and cancer cell proliferation mechanisms.

Application

• Neuroscience Research: Investigation of σ-1 receptor's role in neuropathic pain, depression, anxiety, and addiction models.
• Neurodegenerative Disease Studies: Research into mechanisms of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).
• Oncology Research: Exploration of σ-1 receptor antagonism in cancer cell apoptosis and tumor proliferation studies.
• Pharmacological Profiling: Used in in vitro and in vivo assays to determine receptor binding affinity, selectivity, and functional activity.
• Drug Discovery & Development: A key reference standard and pharmacophore for designing novel therapeutic agents targeting the σ-1 receptor.
• Biochemical Pathway Analysis: Tool for elucidating intracellular calcium signaling, endoplasmic reticulum stress, and mitochondrial function.

Basic Information

Product Name	σ-1 Receptor Antagonist 1
CAS No.	1639220-19-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	σ-1 Receptor Antagonist; σ1R Antagonist; S1RA (related analog class); SR Antagonist; Chaperone Protein Inhibitor; Neuropharmacological Research Compound; σ-1 Receptor Ligand; ER Chaperone Modulator
EINECS	Contact for details

Quality Control

Our σ-1 Receptor Antagonist 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical characterization, including purity assay and identity confirmation via advanced spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product desiccated under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.