Description

R-Avanafil is a high-purity, non-racemic stereoisomer of the active pharmaceutical ingredient Avanafil, identified by CAS NO 1638497-26-3. This specific enantiomer is of critical importance in pharmaceutical research and development for its targeted biological activity and role in creating more efficacious and selective drug formulations. It is primarily required by advanced pharmaceutical manufacturers, research institutions, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel therapeutics for erectile dysfunction and other cardiovascular indications.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of the final Avanafil drug substance.
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and as a benchmark in HPLC, LC-MS, or chiral analysis.
• Preclinical & Clinical Research: Essential for pharmacological studies, pharmacokinetic profiling, and toxicity assessments during drug discovery.
• Process Chemistry & Optimization: Employed in scaling up synthetic routes and developing robust, cost-effective manufacturing processes.
• Regulatory Submission Support: Provides characterized material for stability studies and documentation required for regulatory filings (e.g., FDA, EMA).
• Chiral Catalyst & Resolution Studies: Utilized in research focused on asymmetric synthesis and enantiomeric separation techniques.

Basic Information

Product Name	R-Avanafil
CAS No.	1638497-26-3
Molecular Formula	C23H26ClN7O3
Molecular Weight	483.95 g/mol
Synonyms	(R)-Avanafil; (R)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide; Avanafil R-Enantiomer; (R)-ST-5895; R-Enantiomer of Avanafil; UNII-6I7A8S4W4Q (component); (R)-TA-1790
EINECS	Contact for details

Quality Control

Our R-Avanafil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for chiral purity, assay, and related substances by validated methods such as HPLC and chiral HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-Enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.