Description

Pf-06446846 Hydrochloride is a high-purity chemical intermediate and reference standard of significant interest in pharmaceutical research and development. Its primary value lies in its role as a key building block for the synthesis of novel therapeutic agents, enabling critical structure-activity relationship (SAR) studies. This compound is essential for research organizations, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery programs, particularly those focused on developing small-molecule inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and candidate drugs.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic assays and target validation studies.
• Drug Discovery & Development: Integral to medicinal chemistry efforts for lead optimization and the exploration of new chemical entities.
• Analytical Standard: Employed as a high-purity calibrant in analytical methods development and validation, including HPLC and LC-MS.
• Preclinical Research: Utilized in *in vitro* and *in vivo* studies to assess pharmacokinetic and pharmacodynamic properties.

Basic Information

Product Name	Pf-06446846 Hydrochloride
CAS No.	1632250-50-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PF-06446846 HCl; PF06446846 Hydrochloride; 1632250-50-0; PF 06446846; PF-06446846 hydrochloride salt
EINECS	Contact for details

Quality Control

Our Pf-06446846 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR and/or NMR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.