Description

Protein Degrader 1 (Tfa) is a trifluoroacetic acid (Tfa) salt form of a potent and selective small molecule degrader designed for targeted protein degradation (TPD) research. This compound is a critical tool for investigating novel therapeutic strategies in oncology, neurodegenerative diseases, and other conditions driven by pathogenic proteins. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in molecular biology and drug discovery to validate new targets and develop next-generation PROTACs (Proteolysis Targeting Chimeras).

Application

• Targeted Protein Degradation (TPD) Research: Serves as a key chemical probe for studying PROTAC and molecular glue mechanisms of action.
• Oncology Drug Discovery: Used in preclinical studies to degrade oncogenic driver proteins and evaluate anti-tumor efficacy in cellular and animal models.
• Neurological Disease Research: Applied in models of neurodegenerative diseases to investigate the degradation of misfolded or aggregation-prone proteins like tau or α-synuclein.
• Chemical Biology Tool: Enables the exploration of protein function and the ubiquitin-proteasome system (UPS) in various biological pathways.
• Hit-to-Lead Optimization: Provides a starting point or benchmark for medicinal chemistry programs aimed at improving degrader potency, selectivity, and drug-like properties.
• Biomarker Discovery: Facilitates studies to identify pharmacodynamic biomarkers of target engagement and degradation for clinical translation.

Basic Information

Product Name	Protein Degrader 1 (Tfa)
CAS No.	1631137-51-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Protein Degrader 1 TFA; TFA salt of Protein Degrader 1; Degrader 1 trifluoroacetate; Targeted Protein Degrader 1 (Tfa); (S,R,S)-AHPC-C5-NH2 TFA; VHL Ligand-Linker Conjugate 1 TFA; (2S,4R)-1-((S)-2-(6-(4-Aminobutyl)-1H-indol-3-yl)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide trifluoroacetate
EINECS	Contact for details

Quality Control

Our Protein Degrader 1 (Tfa) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry and NMR, to ensure it meets the high standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.