Description

4-(Difluoromethoxy)Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique difluoromethoxy-piperidine scaffold, which is crucial for modulating the physicochemical and metabolic properties of active pharmaceutical ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the difluoromethoxy group can enhance biological activity and stability.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Acts as a precursor for more complex piperidine derivatives and fluorinated organic compounds.
• Process Chemistry: Employed in scale-up and route development for the commercial manufacturing of fluorinated drug candidates.

Basic Information

Product Name	4-(Difluoromethoxy)Piperidine Hydrochloride
CAS No.	1630907-16-2
Molecular Formula	C7H14ClF2NO
Molecular Weight	201.64 g/mol
Synonyms	4-(Difluoromethoxy)piperidine HCl; Piperidine, 4-(difluoromethoxy)-, hydrochloride; 4-(Difluoromethoxy)piperidine hydrochloride salt; 4-(Difluoromethoxyl)piperidine hydrochloride; 4-(Difluoromethoxy)piperidine HCl salt; 1630907-16-2; 4-DFMP HCl
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.